{"id":69950,"date":"2022-06-15T14:51:08","date_gmt":"2022-06-15T14:51:08","guid":{"rendered":"https:\/\/www.imperialcrs.com\/blog\/?p=69950"},"modified":"2023-12-06T09:23:13","modified_gmt":"2023-12-06T09:23:13","slug":"placebo-effect-5-fun-facts","status":"publish","type":"post","link":"https:\/\/www.imperialcrs.com\/blog\/business-insights\/placebo-effect-5-fun-facts\/","title":{"rendered":"The Placebo Effect: 5 Must-Know Facts"},"content":{"rendered":"<p>Our brains and bodies are complex \u2014 humans are still a fascinating mystery. For a perfect example, how about the placebo effect? Placebos are at the core of clinical trials, and using study placebos helps establish efficacy. Researchers are still trying to understand how and why placebos often produce a physical effect.<\/p>\n<p>Here are five facts about this remarkable subject:<\/p>\n<h2><strong style=\"font-family: Raleway, sans-serif; font-size: 22px; letter-spacing: 0px;\">Placebo is an ancient term.<\/strong><\/h2>\n<p>The word placebo isn\u2019t medical jargon derived by a pharmaceutical company. In fact, it is an old Latin term that means \u201cI shall please,\u201d and it refers to flattering someone.<\/p>\n<h2><strong style=\"font-family: Raleway, sans-serif; font-size: 22px; letter-spacing: 0px;\">The first placebo was a simple wooden rod.<\/strong><\/h2>\n<p>The <a href=\"https:\/\/www.jameslindlibrary.org\/haygarth-j-1800\">first use of a placebo<\/a> was in 1799 by British physician John Haygarth. At the time, a doctor named Elisha Perkins sold expensive metal rods he called Perkins tractors. Perkins claimed his simple devices pulled diseases out of the body, and they became popular. Haygarth demonstrated that the same \u201ctreatment\u201d with simple wooden rods also showed effectiveness.<\/p>\n<h2><strong style=\"font-family: Raleway, sans-serif; font-size: 22px; letter-spacing: 0px;\">The first use of a study placebo in a clinical trial goes back 150+ years.<\/strong><\/h2>\n<p>The <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3149409\/\">first use of a trial placebo<\/a> was in 1863. U.S. physician Austin Flint created the first clinical study comparing placebo to active treatment for rheumatism. His study placebo was an herbal extract. Austin reported: \u201cThis was given regularly and became well known in my wards as the \u2018placeboic remedy\u2019 for rheumatism. The favorable progress of the cases was such as to secure for the remedy generally the entire confidence of the patients.\u201d<\/p>\n<h2><strong style=\"font-family: Raleway, sans-serif; font-size: 22px; letter-spacing: 0px;\">Open-label placebos are effective.<\/strong><\/h2>\n<p>It appears placebos can work even when the <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28452193\/\">patient knows he or she is receiving one<\/a>. In several open-label placebo studies, patients\u2019 symptoms did improve. More detailed studies are needed to fully understand this phenomenon.<\/p>\n<p><strong style=\"font-family: Raleway, sans-serif; font-size: 22px; letter-spacing: 0px;\">The placebo effect can include side effects.<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-69967\" src=\"https:\/\/www.imperialcrs.com\/blog\/wp-content\/uploads\/2022\/06\/Nocebo-effect-300x240.jpeg\" alt=\"Nocebo effect\" width=\"300\" height=\"240\" srcset=\"https:\/\/www.imperialcrs.com\/blog\/wp-content\/uploads\/2022\/06\/Nocebo-effect-300x240.jpeg 300w, https:\/\/www.imperialcrs.com\/blog\/wp-content\/uploads\/2022\/06\/Nocebo-effect-1024x819.jpeg 1024w, https:\/\/www.imperialcrs.com\/blog\/wp-content\/uploads\/2022\/06\/Nocebo-effect-768x614.jpeg 768w, https:\/\/www.imperialcrs.com\/blog\/wp-content\/uploads\/2022\/06\/Nocebo-effect-585x468.jpeg 585w, https:\/\/www.imperialcrs.com\/blog\/wp-content\/uploads\/2022\/06\/Nocebo-effect.jpeg 1080w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>Enter the <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0163834307000114?via%3Dihub\"><em>nocebo effect<\/em><\/a>. Patients can experience a negative response if they are expecting one. For example, if patients are told by the study staff or in the patient materials that one of the possible side effects of a study drug is nausea, participants in the placebo group can experience this side effect. The nocebo has been called the evil twin of the placebo. In one chilling case, a participant in an antidepressant trial decided to overdose on the study drug. He swallowed 29 capsules and arrived at the hospital near death. After receiving life-saving treatments, he was unblinded and found to be in the study placebo arm. After getting this news, his vital signs returned to normal within 15 minutes.<\/p>\n<p>A deep dive into the subject of placebos unveils a Pandora\u2019s box of mysteries, opinions, and ethical questions. In clinical trials, the use of placebos can be a key factor in patient recruitment and retention. See Imogen Cheese\u2019s blog <a href=\"https:\/\/www.imperialcrs.com\/blog\/2022\/06\/14\/study-placebo-use-issues-and-answers\/\">here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our brains and bodies are complex \u2014 humans are still a fascinating mystery. For a perfect example, how about the placebo effect? Placebos are at the core of clinical trials, and using study placebos helps establish efficacy. Researchers are still trying to understand how and&hellip;<\/p>\n","protected":false},"author":37,"featured_media":69966,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22],"tags":[782,789,786,793,785,780,792,790,791,784,794,788,787,783,781],"class_list":["post-69950","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-business-insights","tag-clinical-trials-and-placebo","tag-ethical-considerations-in-placebo-use","tag-medical-research-and-placebo","tag-patient-expectations-in-clinical-trials","tag-placebo-effect-in-healthcare","tag-placebo-effect-insights","tag-placebo-effectiveness","tag-placebo-impact-on-patient-outcomes","tag-placebo-in-drug-development","tag-placebo-response-factors","tag-placebo-response-in-medicine","tag-placebo-response-mechanisms","tag-placebo-controlled-studies","tag-psychology-of-placebo","tag-understanding-placebos"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The Placebo Effect: 5 Must-Know Facts - Imperial Clinical Research Services Blog<\/title>\n<meta name=\"description\" content=\"The placebo effect is a fascinating and mysterious subject. 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